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RARE

Neutral signalScored 2026-10-25 Drivers: Congress, trend, fundamentals. Moteurs : Congrès, tendance, fondamentaux.

Research, not advice.

À propos

Ultragenyx Pharmaceutical Inc.

Nom
Ultragenyx Pharmaceutical Inc.
Secteur
Healthcare
Industrie
Biotechnology
Bourse
NASDAQ
Capitalisation
$1.5B
Employés
1,371
PDG
Emil D. Kakkis
Site web
https://www.ultragenyx.com
Marché
ABEOBBIOBMRNFDMTMGTXMREO

Ultragenyx Pharmaceutical Inc. is a biopharmaceutical firm dedicated to discovering, developing, and commercializing innovative treatments for rare and ultra-rare genetic conditions. Its operations span North America, Europe, and other international markets. The company's portfolio of marketed biologic products addresses several serious diseases. This includes Crysvita (burosumab), an antibody that targets fibroblast growth factor 23, used to treat X-linked hypophosphatemia and tumor-induced osteomalacia. Mepsevii offers enzyme replacement therapy for both pediatric and adult patients suffering from Mucopolysaccharidosis VII. Dojolvi is available for individuals with long-chain fatty acid oxidation disorders, while Evkeeza (evinacumab) provides a treatment option for homozygous familial hypercholesterolemia. Ultragenyx also boasts a robust pipeline of investigational therapies. Notable candidates include DTX401, an adeno-associated virus 8 (AAV8) gene therapy for glycogen storage disease type Ia, and DTX301, another AAV8 gene therapy aimed at ornithine transcarbamylase deficiency. Other promising developments feature UX143, a human monoclonal antibody for osteogenesis imperfecta; GTX-102, an antisense oligonucleotide designed for Angelman syndrome; UX701, targeting Wilson disease; and UX053, in development for glycogen storage disease type III. To advance its research and development efforts, Ultragenyx Pharmaceutical Inc. maintains strategic collaboration and licensing agreements with numerous partners, such as Kyowa Kirin Co., Ltd., Saint Louis University, REGENXBIO Inc., Bayer Healthcare LLC, GeneTx, Mereo, University of Pennsylvania, Arcturus Therapeutics Holdings Inc., Solid Biosciences Inc., and Daiichi Sankyo Co., Ltd. The company was founded in 2010 and operates from its headquarters in Novato, California.

Price (1 year)

Live chart from TradingView — independent market data, as price context around the filings, not the Quorum score. EMA 50/200 and Bollinger load by default. When the exchange is known it is sent as EXCHANGE:SYMBOL; otherwise TradingView resolves the ticker best-effort.

Decouvert par les declarations du Congres

Insiders
—
Total bought
—

Avg buy (VWAP, 90d window) —

Total sold
$291,933

Avg sell (VWAP, 90d window) $19.33 vs last close $16.08 (-16.8%)

Total sold sums Form 4 code S in this window. Codes F, M, A and G are left out.

$181,783 of that total is under a Rule 10b5-1 plan. It is shown here and left out of the score.

Last activity
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Liquidity
Liquid $58,939,599/day · 20d vol
Last synced
2026-10-26 21:10:54 Synced via automated research pipeline

Sign in to request a sync of this company's price history and timing levels.

Insider holdings as a share of total assets aren't available for this company.

Avg buy and avg sell are volume-weighted prices (sum of shares × price, divided by shares) for Form 4 rows in this 90-day window that report both figures. A comparison with last close is market context for that average, not advice.

Recent Form 4

Filings in the 90-day window for this company. Value is shares × price from the filing. Research, not advice.

Date Person Side Shares Price Value Form 4
2026-10-15 Horn Howard Sell · S 7,066 $15.27 $107,898 Form 4
2026-09-15 Huizenga Theodore Alan Sell · S · 10b5-1 1,283 $13.57 $17,410 Form 4
2026-09-03 Huizenga Theodore Alan Sell · S 161 $13.99 $2,252 Form 4
2026-08-03 Horn Howard Sell · S · 10b5-1 4,696 $24.92 $117,024 Form 4
2026-08-03 Parschauer Karah Herdman Sell · S · 10b5-1 1,900 $24.92 $47,348 Form 4

Sales marked 10b5-1 are scheduled in advance and don't count toward the Quorum score. Les ventes marquées 10b5-1 sont planifiées à l'avance et ne pèsent pas dans le score Quorum.

Congressional trades

STOCK Act disclosures (90-day window)

Amounts are STOCK Act brackets as disclosed. Quorum does not turn a bracket into an exact price or a midpoint.

Date Member Side Amount range Filing
2026-09-29 Gilbert Cisneros Buy $1,001 - $15,000 Filing

Recent trades

DateRepresentativeTypeAmount
2026-09-29Gilbert CisnerosPurchase$1,001 - $15,000
2026-03-03Gilbert CisnerosPurchase$1,001 - $15,000
2026-02-18Gilbert CisnerosPurchase$1,001 - $15,000
2025-08-08Gilbert CisnerosPurchase$1,001 - $15,000
2025-07-15Gilbert CisnerosPurchase$1,001 - $15,000
2022-01-21Ro KhannaSale$1,001 - $15,000
2022-01-11Ro KhannaSale$1,001 - $15,000
2021-08-30Kurt SchraderPurchase$1,001 - $15,000

Signal

Neutral signalScored 2026-10-25 Drivers: Congress, trend, fundamentals. Moteurs : Congrès, tendance, fondamentaux.

RARE presents a moderate event-driven signal anchored by congressional purchases and two significant PRV sales ($203M and $210M) providing non-dilutive cash injections, partially offsetting deeply stressed fundamentals.

The first sentence of the analysis written for RARE on 2026-10-25 - a real excerpt, not a sample. The rest of it, the 0-100 score and the rating it produced are part of Plus. See plans.

Neutral signal Drivers: Congress, trend, fundamentals. Moteurs : Congrès, tendance, fondamentaux.

Factor checklist — research, not advice

A check leans with a bullish reading. A cross leans against it. A dash is unavailable or mixed.

  • Insider Pulls against a bullish reading. Selling cluster — sale value, no purchase value
  • Narrative Unavailable or mixed. Stored narrative reading is in the neutral band
  • Congress Supports a bullish reading. 3 purchase disclosures year to date
  • Timing Pulls against a bullish reading. Close is more than 0.5 ATR under stored support
  • Financial indicators Unavailable or mixed. Current ratio 2.48 · operating margin -79% — readings disagree

Suggested stop 14.50, nearest stored support minus 0.5 ATR(9.8% under the last close). Reward/risk to the next stored resistance is 4.14. Research, not advice. Not an order.

Recent news

Market snapshot

Financial ratios

MetricTrend2025-12-312024-12-312023-12-312022-12-312021-12-31
Gross Profit Margin83.8%86.3%89.6%92.2%95.4%
Ebit Margin-75.6%-90.1%-124.9%-181.3%-120.5%
Ebitda Margin-70.4%-83.7%-118.9%-176.3%-116.8%
Operating Profit Margin-79.5%-95.7%-131.1%-178.6%-108.6%
Pretax Profit Margin-84.8%-101.3%-140.1%-193.1%-128.9%
Continuous Operations Profit Margin-85.4%-101.6%-139.7%-194.7%-129.2%
Net Profit Margin-85.4%-101.6%-139.7%-194.7%-129.2%
Bottom Line Profit Margin-85.4%-101.6%-139.7%-194.7%-129.2%
Current Ratio2.4772.3742.6113.3844.723
Quick Ratio2.3412.2442.4903.2814.634
Solvency Ratio-0.336-0.430-0.478-0.578-0.735
Cash Ratio1.1300.5050.7620.5091.696
Price To Earnings Ratio-3.945-6.688-5.796-4.578-12.551
Price To Earnings Growth Ratio0.5390.2820.314-0.090-0.106
Forward Price To Earnings Growth Ratio0.5390.2820.314-0.090-0.106
Price To Earnings Diluted Ratio-3.945-6.688-5.796-4.578-12.551
Price To Earnings Diluted Growth Ratio0.5390.2820.314-0.090-0.106
Price To Book Ratio-28.34814.92012.7699.1896.179
Price To Sales Ratio3.3706.7998.0998.91516.223
Price To Free Cash Flow Ratio-4.805-9.033-6.743-6.151-13.844
Price To Operating Cash Flow Ratio-4.867-9.196-7.407-8.514-16.832
Debt To Assets Ratio0.8330.0270.0290.0200.028
Debt To Equity Ratio-15.9500.1580.1570.0900.045
Debt To Capital Ratio1.0670.1360.1360.0820.044
Long Term Debt To Capital Ratio1.0730.0000.0000.0000.000
Financial Leverage Ratio-19.1505.8895.4144.3841.650
Working Capital Turnover Ratio1.2941.2120.8080.5600.395
Operating Cash Flow Ratio-1.214-1.203-1.693-1.457-1.867
Operating Cash Flow Sales Ratio-0.692-0.739-1.093-1.047-0.964
Free Cash Flow Operating Cash Flow Ratio1.0131.0181.0981.3841.216
Debt Service Coverage Ratio-3.343-7.465-7.797-15.022-13.982
Interest Coverage Ratio-8.629-8.502-8.624-15.086-12.975
Short Term Operating Cash Flow Coverage Ratio-5.7530.0000.0000.0000.000
Operating Cash Flow Coverage Ratio-0.365-10.268-10.999-12.043-8.070
Capital Expenditure Coverage Ratio-77.667-55.291-10.153-2.604-4.634
Dividend Paid And Capex Coverage Ratio-77.667-55.291-10.153-2.604-4.634
Dividend Payout Ratio0.0000.0000.0000.0000.000
Enterprise Value Multiple-6.561-7.837-6.480-4.899-13.247

Sparkline shows each ratio oldest → newest (left → right).

How the latest year compares

For each ratio: its most recent value, the change versus one year earlier, and versus its 5-year average. ▲ higher ▼ lower

MetricCurrentvs 1Y agovs 5Y avg
Gross Profit Margin 83.8% ▼-2.5% ▼-5.7%
Ebit Margin -75.6% ▲14.4% ▲42.9%
Ebitda Margin -70.4% ▲13.3% ▲42.8%
Operating Profit Margin -79.5% ▲16.2% ▲39.2%
Pretax Profit Margin -84.8% ▲16.5% ▲44.8%
Continuous Operations Profit Margin -85.4% ▲16.2% ▲44.7%
Net Profit Margin -85.4% ▲16.2% ▲44.7%
Bottom Line Profit Margin -85.4% ▲16.2% ▲44.7%
Current Ratio 2.477 ▲0.102 ▼-0.637
Quick Ratio 2.341 ▲0.098 ▼-0.657
Solvency Ratio -0.336 ▲0.093 ▲0.175
Cash Ratio 1.130 ▲0.625 ▲0.210
Price To Earnings Ratio -3.945 ▲2.743 ▲2.767
Price To Earnings Growth Ratio 0.539 ▲0.258 ▲0.352
Forward Price To Earnings Growth Ratio 0.539 ▲0.258 ▲0.352
Price To Earnings Diluted Ratio -3.945 ▲2.743 ▲2.767
Price To Earnings Diluted Growth Ratio 0.539 ▲0.258 ▲0.352
Price To Book Ratio -28.348 ▼-43.267 ▼-31.290
Price To Sales Ratio 3.370 ▼-3.429 ▼-5.311
Price To Free Cash Flow Ratio -4.805 ▲4.228 ▲3.311
Price To Operating Cash Flow Ratio -4.867 ▲4.330 ▲4.497
Debt To Assets Ratio 0.833 ▲0.806 ▲0.646
Debt To Equity Ratio -15.950 ▼-16.108 ▼-12.850
Debt To Capital Ratio 1.067 ▲0.930 ▲0.774
Long Term Debt To Capital Ratio 1.073 ▲1.073 ▲0.859
Financial Leverage Ratio -19.150 ▼-25.039 ▼-18.788
Working Capital Turnover Ratio 1.294 ▲0.083 ▲0.441
Operating Cash Flow Ratio -1.214 ▼-0.010 ▲0.273
Operating Cash Flow Sales Ratio -0.692 ▲0.047 ▲0.215
Free Cash Flow Operating Cash Flow Ratio 1.013 ▼-0.005 ▼-0.133
Debt Service Coverage Ratio -3.343 ▲4.122 ▲6.179
Interest Coverage Ratio -8.629 ▼-0.127 ▲2.134
Short Term Operating Cash Flow Coverage Ratio -5.753 ▼-5.753 ▼-4.603
Operating Cash Flow Coverage Ratio -0.365 ▲9.902 ▲7.984
Capital Expenditure Coverage Ratio -77.667 ▼-22.375 ▼-47.597
Dividend Paid And Capex Coverage Ratio -77.667 ▼-22.375 ▼-47.597
Dividend Payout Ratio 0.000 0.000 0.000
Enterprise Value Multiple -6.561 ▲1.276 ▲1.244

Key metrics

MetricTrend20252024202320222021
Market cap$2.27B$3.81B$3.52B$3.24B$5.70B
Enterprise value$3.11B$3.68B$3.35B$3.14B$5.44B
EV / Sales4.62x6.56x7.71x8.64x15.47x
EV / Op. cash flow-6.67x-8.87x-7.05x-8.25x-16.05x
EV / Free cash flow-6.59x-8.72x-6.42x-5.96x-13.20x
EV / EBITDA-6.56x-7.84x-6.48x-4.90x-13.25x
Net debt / EBITDA-1.78x0.28x0.33x0.16x0.65x
Current ratio2.48x2.37x2.61x3.38x4.72x
Income quality0.81x0.73x0.78x0.54x0.75x
Graham net-net-$8-$6-$8-$6$3
Tax burden100.7%100.3%99.7%100.8%100.2%
Interest burden112.2%112.5%112.2%106.5%106.9%
Working capital$567.0M$473.0M$451.7M$622.7M$675.2M
Invested capital$1.05B$961.6M$953.0M$1.09B$1.03B
Return on assets-37.5%-37.9%-40.7%-45.8%-29.8%
Operating ROA-35.3%-35.8%-37.5%-42.3%-23.3%
Return on tangible assets-43.8%-44.4%-47.4%-52.8%-33.7%
Return on equity718.8%-222.9%-220.3%-200.7%-49.2%
Return on invested capital-43.5%-45.8%-46.4%-50.1%-28.2%
Return on capital employed-46.6%-46.2%-47.0%-50.5%-28.5%
Earnings yield-25.4%-14.9%-17.2%-21.8%-8.0%
Free cash flow yield-20.8%-11.1%-14.8%-16.3%-7.2%
Capex / Op. cash flow-1.3%-1.8%-9.8%-38.4%-21.6%
Capex / Depreciation17.1%21.1%179.8%802.0%552.1%
Capex / Sales0.9%1.3%10.8%40.2%20.8%
SG&A / Sales51.9%57.4%71.3%76.6%62.6%
R&D / Sales111.4%124.6%149.3%194.3%141.5%
Stock comp / Sales22.7%28.2%31.1%35.9%29.9%
Intangibles / Total assets14.4%14.8%14.1%13.2%11.5%
Days sales outstanding86d79d62d41d46d
Days payables outstanding104d184d340d558d391d
Operating cycle260d293d336d386d416d
Cash conversion cycle157d109d-4d-172d25d

Change by theme

Grouped by what each metric measures. Each figure is the change over the period shown — ▲ up ▼ down versus then.

Change over 1 year

Valuation
Market cap ▼-40.5%EV / Sales ▼-29.6%EV / EBITDA ▲+16.3%EV / Op. cash flow ▲+2.201Earnings yield ▼-0.104
Profitability
Return on equity ▲+9.417Return on assets ▲+0.003Return on invested capital ▲+0.023Return on capital employed ▼-0.004Operating ROA ▲+0.005Income quality ▲+0.083Tax burden ▲+0.004
Efficiency
Days sales outstanding ▲+6.878Days payables outstanding ▼-80.557Operating cycle ▼-33.095Cash conversion cycle ▲+47.462Capex / Sales ▼-0.004R&D / Sales ▼-0.131
Balance-sheet strength
Current ratio ▲+0.102Net debt / EBITDA ▼-2.061Working capital ▲+94030000.000Invested capital ▲+92381000.000Intangibles / Total assets ▼-0.005

Change over 5 years

Valuation
Market cap ▼-60.2%EV / Sales ▼-70.1%EV / EBITDA ▲+50.5%EV / Op. cash flow ▲+9.374Earnings yield ▼-0.174
Profitability
Return on equity ▲+7.680Return on assets ▼-0.077Return on invested capital ▼-0.153Return on capital employed ▼-0.181Operating ROA ▼-0.120Income quality ▲+0.064Tax burden ▲+0.005
Efficiency
Days sales outstanding ▲+40.082Days payables outstanding ▼-286.958Operating cycle ▼-155.874Cash conversion cycle ▲+131.084Capex / Sales ▼-0.199R&D / Sales ▼-0.300
Balance-sheet strength
Current ratio ▼-2.246Net debt / EBITDA ▼-2.424Working capital ▼-108236000.000Invested capital ▲+27387000.000Intangibles / Total assets ▲+0.029

Employee count

Peer market caps