← Insiders

TWST

Bearish signalScored 2026-10-27 Drivers: Congress, trend, fundamentals. Moteurs : Congrès, tendance, fondamentaux.

Research, not advice.

À propos

Twist Bioscience Corporation

Nom
Twist Bioscience Corporation
Secteur
Healthcare
Industrie
Biotechnology
Bourse
NASDAQ
Capitalisation
$9.1B
Employés
979
PDG
Emily Marine Leproust
Site web
https://www.twistbioscience.com
Marché
GNNSFLZAGYRGENSDMHFWUXIFWXIBF

Twist Bioscience Corporation operates as a leading synthetic biology firm, specializing in the production and sale of products developed from synthesized DNA. The company utilizes a unique DNA synthesis platform that facilitates the creation of artificial DNA by "writing" it directly onto silicon chips. Its extensive product catalog encompasses custom synthetic genes, specialized tools designed for sample preparation, comprehensive antibody libraries essential for pharmaceutical research and development, and advanced applications leveraging DNA for digital data storage. Twist Bioscience has established strategic collaborations with several organizations, including Victorian Clinical Genetic Services, Vivlion GmbH, Kyowa Kirin Pharmaceutical Research, Inc., deepCDR Biologics AG, and Centogene N.V., with the shared goal of innovating advanced sequencing technologies. Furthermore, the company engages in a research alliance with Boehringer Ingelheim International GmbH, where it applies its exclusive antibody libraries to identify and develop therapeutic antibodies against a multitude of targets. The corporation was founded in 2013 and is headquartered in South San Francisco, California.

Price (1 year)

Live chart from TradingView — independent market data, as price context around the filings, not the Quorum score. EMA 50/200 and Bollinger load by default. When the exchange is known it is sent as EXCHANGE:SYMBOL; otherwise TradingView resolves the ticker best-effort.

VENTE TOTALE: 416 677 titres (~65 157 503,08 $ US)

Insiders
Leproust Emily M.
Total bought
—

Avg buy (VWAP, 90d window) —

Total sold
$46,620,914

Avg sell (VWAP, 90d window) $143.97 vs last close $145.25 (+0.9%)

Total sold sums Form 4 code S in this window. Codes F, M, A and G are left out.

$29,431,073 of that total is under a Rule 10b5-1 plan. It is shown here and left out of the score.

Last activity
2026-10-05
Liquidity
Liquid $454,305,048/day · 20d vol
Last synced
2026-10-27 06:51:29 Synced via automated research pipeline

Sign in to request a sync of this company's price history and timing levels.

Insider holdings as a share of total assets aren't available for this company.

Avg buy and avg sell are volume-weighted prices (sum of shares × price, divided by shares) for Form 4 rows in this 90-day window that report both figures. A comparison with last close is market context for that average, not advice.

Recent Form 4

Filings in the 90-day window for this company. Value is shares × price from the filing. Research, not advice.

Date Person Side Shares Price Value Form 4
2026-10-09 Laponis Adam Sell · S 2,462 $156.30 $384,823 Form 4
2026-10-05 Leproust Emily M. Sell · S · 10b5-1 45 $207.46 $9,336 Form 4
2026-10-02 Cho Dennis Sell · S 9,514 $188.88 $1,797,042 Form 4
2026-10-02 Finn Patrick John Sell · S 25,714 $188.88 $4,856,963 Form 4
2026-10-02 Green Paula Sell · S 10,088 $188.88 $1,905,462 Form 4
2026-10-02 Laponis Adam Sell · S 8,057 $188.88 $1,521,838 Form 4
2026-10-02 Leproust Emily M. Sell · S · 10b5-1 45,736 $188.88 $8,638,799 Form 4
2026-10-02 WERNER ROBERT F. Sell · S 1,482 $188.88 $279,926 Form 4
2026-10-01 Leproust Emily M. Sell · S · 10b5-1 655 $200.00 $131,000 Form 4
2026-09-24 Leproust Emily M. Sell · S · 10b5-1 83 $184.60 $15,322 Form 4
2026-09-21 Cho Dennis Sell · S 348 $165.49 $57,591 Form 4
2026-09-21 Green Paula Sell · S 294 $165.49 $48,654 Form 4
2026-09-21 Leproust Emily M. Sell · S 1,687 $165.49 $279,183 Form 4
2026-09-17 Leproust Emily M. Sell · S · 10b5-1 869 $163.39 $141,988 Form 4
2026-09-08 Cho Dennis Sell · S 412 $122.62 $50,521 Form 4
2026-09-08 Green Paula Sell · S 907 $122.62 $111,220 Form 4
2026-09-08 Leproust Emily M. Sell · S 2,302 $122.62 $282,280 Form 4
2026-09-08 WERNER ROBERT F. Sell · S 238 $122.62 $29,185 Form 4
2026-08-25 Leproust Emily M. Sell · S · 10b5-1 1,093 $154.45 $168,809 Form 4
2026-08-24 WERNER ROBERT F. Sell · S 854 $140.77 $120,220 Form 4
2026-08-21 Cho Dennis Sell · S 1,598 $139.07 $222,227 Form 4
2026-08-21 Finn Patrick John Sell · S 4,046 $139.07 $562,661 Form 4
2026-08-21 Green Paula Sell · S 1,360 $139.07 $189,130 Form 4
2026-08-21 Laponis Adam Sell · S 1,965 $139.07 $273,265 Form 4
2026-08-21 Leproust Emily M. Sell · S 6,639 $139.07 $923,259 Form 4
2026-08-21 WERNER ROBERT F. Sell · S 669 $139.07 $93,035 Form 4
2026-08-19 Cho Dennis Sell · S · 10b5-1 14,205 $129.75 $1,843,099 Form 4
2026-08-18 Finn Patrick John Sell · S · 10b5-1 2,000 $122.58 $245,162 Form 4
2026-08-12 BLAKE KATRYN Sell · S 2,240 $122.88 $275,251 Form 4
2026-08-12 Leproust Emily M. Sell · S · 10b5-1 19,952 $125.08 $2,495,508 Form 4
2026-08-10 Leproust Emily M. Sell · S · 10b5-1 113,318 $125.16 $14,183,051 Form 4
2026-08-07 CHESS ROBERT Sell · S 18,417 $110.89 $2,042,261 Form 4
2026-08-05 Cho Dennis Sell · S · 10b5-1 14,205 $109.75 $1,558,999 Form 4
2026-08-03 Cho Dennis Sell · S 1,070 $85.32 $91,294 Form 4
2026-08-03 Finn Patrick John Sell · S 2,888 $85.32 $246,408 Form 4
2026-08-03 Green Paula Sell · S 1,133 $85.32 $96,669 Form 4
2026-08-03 Leproust Emily M. Sell · S 5,101 $85.32 $435,223 Form 4
2026-08-03 WERNER ROBERT F. Sell · S 167 $85.32 $14,249 Form 4

Sales marked 10b5-1 are scheduled in advance and don't count toward the Quorum score. Les ventes marquées 10b5-1 sont planifiées à l'avance et ne pèsent pas dans le score Quorum.

Congressional trades

STOCK Act disclosures (90-day window)

Amounts are STOCK Act brackets as disclosed. Quorum does not turn a bracket into an exact price or a midpoint.

No STOCK Act disclosures for this company in this window.

Recent trades

DateRepresentativeTypeAmount
2020-03-02Dwight EvansPurchase$1,001 - $15,000

Signal

Bearish signalScored 2026-10-27 Drivers: Congress, trend, fundamentals. Moteurs : Congrès, tendance, fondamentaux.

Despite solid financial health indicators (liquidity 75, fundamentals trend 65) with narrowing losses and gross margin expansion, the near-zero catalyst score (10) driven by massive insider selling ($65M by Leproust…

The first sentence of the analysis written for TWST on 2026-10-27 - a real excerpt, not a sample. The rest of it, the 0-100 score and the rating it produced are part of Plus. See plans.

Bearish signal Drivers: Congress, trend, fundamentals. Moteurs : Congrès, tendance, fondamentaux.

Factor checklist — research, not advice

A check leans with a bullish reading. A cross leans against it. A dash is unavailable or mixed.

  • Insider Pulls against a bullish reading. Selling cluster — sale value, no purchase value
  • Narrative Pulls against a bullish reading. Stored narrative reading is in the bearish band
  • Congress Unavailable or mixed. 1 purchase disclosure year to date, a thin reading
  • Timing Pulls against a bullish reading. Close is more than 0.5 ATR under stored support
  • Financial indicators Unavailable or mixed. Current ratio 3.64 · operating margin -36% — readings disagree

Suggested stop 124.04, nearest stored support minus 0.5 ATR(14.6% under the last close). Reward/risk to the next stored resistance is 0.48. Wait — that reward/risk is under 2. Research, not advice. Not an order.

Recent news

Market snapshot

Financial ratios

MetricTrend2025-09-302024-09-302023-09-302022-09-302021-09-30
Gross Profit Margin50.7%42.6%36.6%41.4%39.1%
Ebit Margin-20.4%-66.5%-83.0%-112.1%-116.1%
Ebitda Margin-13.8%-56.5%-71.1%-104.0%-108.7%
Operating Profit Margin-36.2%-70.6%-88.6%-115.3%-115.4%
Pretax Profit Margin-20.4%-66.5%-83.0%-112.1%-116.4%
Continuous Operations Profit Margin-20.6%-66.7%-83.5%-107.0%-114.9%
Net Profit Margin-20.6%-66.7%-83.5%-107.0%-114.9%
Bottom Line Profit Margin-20.6%-66.7%-83.5%-107.0%-114.9%
Current Ratio3.6434.8845.7866.5798.667
Quick Ratio3.3334.5455.3496.1468.163
Solvency Ratio-0.313-1.252-1.146-1.171-1.174
Cash Ratio2.0033.1873.9074.1777.388
Price To Earnings Ratio-21.646-12.550-5.628-8.723-33.959
Price To Earnings Growth Ratio0.3390.0000.517-0.3092.886
Forward Price To Earnings Growth Ratio0.3390.0000.517-0.3092.886
Price To Earnings Diluted Ratio-21.646-12.550-5.628-8.723-33.959
Price To Earnings Diluted Growth Ratio0.3390.0000.517-0.3092.886
Price To Book Ratio3.5585.5451.8492.4068.886
Price To Sales Ratio4.4698.3754.7029.32839.003
Price To Free Cash Flow Ratio-22.252-37.895-6.769-8.393-37.051
Price To Operating Cash Flow Ratio-35.336-40.896-8.089-15.266-45.984
Debt To Assets Ratio0.2140.1380.1210.0990.090
Debt To Equity Ratio0.2900.1800.1510.1200.108
Debt To Capital Ratio0.2250.1520.1310.1070.098
Long Term Debt To Capital Ratio0.1150.0000.0000.0000.000
Financial Leverage Ratio1.3571.3001.2451.2181.209
Working Capital Turnover Ratio1.4560.9990.5720.4120.338
Operating Cash Flow Ratio-0.521-0.903-1.943-1.372-1.780
Operating Cash Flow Sales Ratio-0.126-0.205-0.581-0.611-0.848
Free Cash Flow Operating Cash Flow Ratio1.5881.0791.1951.8191.241
Debt Service Coverage Ratio-3.821-6,112.586-35,060.600-2,515.863-73.987
Interest Coverage Ratio0.000-7,614.862-43,431.800-2,934.700-416.147
Short Term Operating Cash Flow Coverage Ratio-3.4460.0000.0000.000-72.322
Operating Cash Flow Coverage Ratio-0.347-0.754-1.515-1.311-1.784
Capital Expenditure Coverage Ratio-1.701-12.627-5.129-1.221-4.148
Dividend Paid And Capex Coverage Ratio-1.701-12.627-5.129-1.221-4.148
Dividend Payout Ratio0.0000.0000.0000.0000.000
Enterprise Value Multiple-31.427-14.034-5.513-7.630-33.066

Sparkline shows each ratio oldest → newest (left → right).

How the latest year compares

For each ratio: its most recent value, the change versus one year earlier, and versus its 5-year average. ▲ higher ▼ lower

MetricCurrentvs 1Y agovs 5Y avg
Gross Profit Margin 50.7% ▲8.1% ▲8.6%
Ebit Margin -20.4% ▲46.1% ▲59.2%
Ebitda Margin -13.8% ▲42.6% ▲57.0%
Operating Profit Margin -36.2% ▲34.4% ▲49.0%
Pretax Profit Margin -20.4% ▲46.1% ▲59.3%
Continuous Operations Profit Margin -20.6% ▲46.1% ▲57.9%
Net Profit Margin -20.6% ▲46.1% ▲57.9%
Bottom Line Profit Margin -20.6% ▲46.1% ▲57.9%
Current Ratio 3.643 ▼-1.241 ▼-2.269
Quick Ratio 3.333 ▼-1.212 ▼-2.174
Solvency Ratio -0.313 ▲0.939 ▲0.698
Cash Ratio 2.003 ▼-1.185 ▼-2.130
Price To Earnings Ratio -21.646 ▼-9.096 ▼-5.145
Price To Earnings Growth Ratio 0.339 ▲0.339 ▼-0.348
Forward Price To Earnings Growth Ratio 0.339 ▲0.339 ▼-0.348
Price To Earnings Diluted Ratio -21.646 ▼-9.096 ▼-5.145
Price To Earnings Diluted Growth Ratio 0.339 ▲0.339 ▼-0.348
Price To Book Ratio 3.558 ▼-1.987 ▼-0.890
Price To Sales Ratio 4.469 ▼-3.906 ▼-8.706
Price To Free Cash Flow Ratio -22.252 ▲15.642 ▲0.220
Price To Operating Cash Flow Ratio -35.336 ▲5.559 ▼-6.222
Debt To Assets Ratio 0.214 ▲0.075 ▲0.082
Debt To Equity Ratio 0.290 ▲0.111 ▲0.120
Debt To Capital Ratio 0.225 ▲0.073 ▲0.082
Long Term Debt To Capital Ratio 0.116 ▲0.116 ▲0.092
Financial Leverage Ratio 1.357 ▲0.058 ▲0.091
Working Capital Turnover Ratio 1.456 ▲0.457 ▲0.701
Operating Cash Flow Ratio -0.521 ▲0.382 ▲0.783
Operating Cash Flow Sales Ratio -0.127 ▲0.078 ▲0.348
Free Cash Flow Operating Cash Flow Ratio 1.588 ▲0.509 ▲0.203
Debt Service Coverage Ratio -3.821 ▲6108.765 ▲8749.550
Interest Coverage Ratio 0.000 ▲7614.862 ▲10879.502
Short Term Operating Cash Flow Coverage Ratio -3.446 ▼-3.446 ▲11.708
Operating Cash Flow Coverage Ratio -0.347 ▲0.407 ▲0.795
Capital Expenditure Coverage Ratio -1.701 ▲10.926 ▲3.264
Dividend Paid And Capex Coverage Ratio -1.701 ▲10.926 ▲3.264
Dividend Payout Ratio 0.000 0.000 0.000
Enterprise Value Multiple -31.427 ▼-17.393 ▼-13.093

Key metrics

MetricTrend20252024202320222021
Market cap$1.68B$2.62B$1.15B$1.90B$5.16B
Enterprise value$1.64B$2.48B$960.1M$1.62B$4.76B
EV / Sales4.35x7.92x3.92x7.93x35.96x
EV / Op. cash flow-34.38x-38.69x-6.74x-12.98x-42.39x
EV / Free cash flow-21.65x-35.85x-5.64x-7.14x-34.16x
EV / EBITDA-31.43x-14.03x-5.51x-7.63x-33.07x
Net debt / EBITDA0.88x0.80x1.10x1.34x2.80x
Current ratio3.64x4.88x5.79x6.58x8.67x
Income quality0.61x0.31x0.70x0.57x0.74x
Graham net-net$2$3$4$7$8
Tax burden100.9%100.3%100.6%95.4%98.7%
Interest burden100.0%100.0%100.0%100.0%100.2%
Working capital$241.6M$275.8M$350.9M$505.8M$483.4M
Invested capital$488.8M$537.4M$694.6M$865.8M$629.8M
Return on assets-12.1%-34.0%-26.4%-22.7%-21.7%
Operating ROA-21.7%-31.8%-25.0%-28.2%-27.7%
Return on tangible assets-14.2%-40.6%-32.2%-26.7%-23.0%
Return on equity-16.4%-44.2%-32.8%-27.6%-26.2%
Return on invested capital-24.1%-39.6%-30.2%-25.3%-23.2%
Return on capital employed-24.8%-40.6%-30.9%-27.0%-23.9%
Earnings yield-4.6%-8.0%-17.8%-11.5%-2.9%
Free cash flow yield-4.5%-2.6%-14.8%-11.9%-2.7%
Capex / Op. cash flow-58.8%-7.9%-19.5%-81.9%-24.1%
Capex / Depreciation112.7%16.1%94.8%616.8%277.5%
Capex / Sales7.4%1.6%11.3%50.0%20.4%
SG&A / Sales65.6%69.8%77.4%104.6%102.7%
R&D / Sales21.3%29.0%43.6%59.1%52.2%
Stock comp / Sales17.1%16.3%12.4%39.1%28.0%
Intangibles / Total assets14.9%16.3%18.1%15.1%5.8%
Days sales outstanding56d41d66d72d79d
Days payables outstanding22d3d33d61d67d
Operating cycle111d90d141d192d223d
Cash conversion cycle89d86d108d131d155d

Change by theme

Grouped by what each metric measures. Each figure is the change over the period shown — ▲ up ▼ down versus then.

Change over 1 year

Valuation
Market cap ▼-35.8%EV / Sales ▼-45.1%EV / EBITDA ▼-123.9%EV / Op. cash flow ▲+4.315Earnings yield ▲+0.033
Profitability
Return on equity ▲+0.277Return on assets ▲+0.219Return on invested capital ▲+0.154Return on capital employed ▲+0.159Operating ROA ▲+0.101Income quality ▲+0.306Tax burden ▲+0.007
Efficiency
Days sales outstanding ▲+14.853Days payables outstanding ▲+18.509Operating cycle ▲+21.607Cash conversion cycle ▲+3.098Capex / Sales ▲+0.058R&D / Sales ▼-0.077
Balance-sheet strength
Current ratio ▼-1.241Net debt / EBITDA ▲+0.078Working capital ▼-34210000.000Invested capital ▼-48568000.000Intangibles / Total assets ▼-0.014

Change over 5 years

Valuation
Market cap ▼-67.4%EV / Sales ▼-87.9%EV / EBITDA ▲+5.0%EV / Op. cash flow ▲+8.018Earnings yield ▼-0.017
Profitability
Return on equity ▲+0.098Return on assets ▲+0.096Return on invested capital ▼-0.009Return on capital employed ▼-0.009Operating ROA ▲+0.060Income quality ▼-0.125Tax burden ▲+0.022
Efficiency
Days sales outstanding ▼-23.186Days payables outstanding ▼-45.638Operating cycle ▼-111.476Cash conversion cycle ▼-65.839Capex / Sales ▼-0.130R&D / Sales ▼-0.309
Balance-sheet strength
Current ratio ▼-5.025Net debt / EBITDA ▼-1.922Working capital ▼-241883000.000Invested capital ▼-141001000.000Intangibles / Total assets ▲+0.091

Employee count

Peer market caps